During the Reformation, Sabinov was known for his education, with several excellent teachers applying the most modern teaching methods. From October 1740, there was a Piarist grammar school in Sabinov, which in 1784 moved to its own building, today's museum. In the years 1867 - 1877, the important Štúrovec Bohuš Nosák-Nezabudov lived with his brother in the town, and the progressive teacher Samuel Fábry and the Slovak poet Ján Cuker also worked here. In the period after the First World War, the visual artists Bandy Cirbus and Ernest Stenhura also coveted and created the writers Jolana Cirbusová and Anton Prídavok. Later, various cultural circles and organizations were established in the city. In the years 1922 - 1924, the Palárik theater circle successfully worked under the direction of Janek Borodáč, who worked in Sabinov as a teacher.
The life of the city, like the whole of Europe, was marked in the first half of our century by the world economic crisis, which resulted in the II. world war. Her hardships also affected Sabinovč hard. Most of the Jews, many of whom were in Sabinov at the time, were taken to the infamous concentration camps, of which few returned. In January 1945, the town was liberated by the rapid advance of the Red Army troops from Dukla through Prešov and Bardejov to the west.