At the end of the 13th century, the Hungarian nobleman Matúš Čák Trenčiansky seized Bojnice and the castle belonged to him until 1321. After Matúš Čák, other aristocratic families took over as owners in Bojnice in the 14th and 15th centuries - Gilethovci, Leustachovci, Noffryovci.
In 1489, King Matej Korvín donated Bojnice Castle together with the manor to his illegitimate son Ján Korvín. After the death of King Matej, the castle was seized by Zápoľský's troops and inhabited until 1526. In 1527, King Ferdinand I donated the castle to Alexei Turz. The Turz family modified the castle and rebuilt it into a comfortable Renaissance mansion. The original Gothic castle thus acquired the character of a Renaissance chateau with equally tall residential buildings grouped around the inner courtyard.
After the extinction of the Turzov family (in 1636), the castle again belonged to the crown. A year later, in 1637, Emperor Ferdinand III. the Bojnice estate to Pavel Pálfi in advance for two hundred thousand gold pieces. In 1643, the Pálfi family received the heritage of Bojnice Castle. In Bojnice, the construction industry took over again and the castle got a baroque appearance. Construction activity at the castle subsided at the end of the 17th century. Its appearance did not change significantly during the 18th and 19th centuries.